Dioscorea species: source of saponin derived anti-inflammatory drugs to fight against complex regional pain syndrome

Abstract published

 

International Conference on Neurosciences, Theme: “Brain Plasticity and Neurological disorders”. 9^th to 11^th November 2013, Department of Zoology, School of Life Sciences, Ravenshaw University, Cuttack, India, pp-36-37.

Dioscorea species: source of saponin derived anti-inflammatory drugs to fight against complex regional pain syndrome

Sanjeet Kumar, Nihar Ranjan Singh, Shanti Prava Behera, Shakti Kanth Rath and Padan Kumar Jena

Email-Id: sanjeet.biotech@gmail.com

Abstract

Complex regional pain syndrome (CRPS) or causalgia is a chronic systematic diseases characterized by severe pain and swelling. It initially affects an arm or a leg and often spreads throughout the body. It is a multifactorial disorder with inflammation, sensitization and maladaptive neuroplasticity. The major treatments are scrambler therapy, contrast bath therapy, mirror box therapy, symapthectomy, use of ketamine and anti-inflammation drugs.anti-inflammation drugs are very important to treat this syndrome. There are list of anti-inflammation synthetic drugs such as aspirin, ibuprofen, diclofence etc. Those are used all over the world. One isolated saponin derived compound, diosgenin from Dioscorea species is very common, which acts as aspirin and possess acute anti-inflammatory and analgesic effects. The isolated saponin (3-beta-2-acetoxy-benzoyl-diosgenin) from Dioscorea zingibenensis showed 7.92 % and 14.51 % anti-inflammatory activities at the dose of 126 mg/kg and 252 mg/kg body weight in mice (Mh et al., 2011). Keeping this in view an investigation was made to screen the saponin in three solvents n-hexane, methanol and water with polarity 0.1, 5.1 and 10.0 respectively in tuber of four Dioscorea species i.e. Dioscorea puber, Dioscorea pentaphylla, Dioscorea bulbifera and Dioscorea alata. The species are prevalent in Odisha. Results showed presence of 99.0 % of saponin in water, 33.3 % in methanol and no indication of saponin in n-hexane extract. Further studies are being carried out to validate the anti-inflammatory activity of the isolated saponin of above Dioscorea species. Such investigation will be helpful and will provide base to formulate synthetic drug to fight against CRPS.

Antibacterial and Phytochemical Evaluation of Dioscorea alata L.: a medicinal food crop of rural Odisha

Abstract published

 

National Seminar on “Innovations in Science & Technology for inclusive development” organised by Indian Science Congress Association on the occasion of the 16^th Odisha Bigyan Congress, November 23-24, 2013 at Institute of Physics, Bhubaneshwar, pp-143.

Antibacterial and Phytochemical Evaluation of Dioscorea alata L.: a medicinal food crop of rural Odisha

Sanjeet Kumar

A. Singh, S. P. Behera, S.K.Rath, N.R.Singh and P.K.Jena

Department of Botany, Ravenshaw University, Cuttack-753003

Email-Id: sanjeet.biotech@gmail.com

Abstract

Dioscorea alata L., commonly known as Mati aalu, is a monocot vine having tuberous root along with aerial edible bulbils. It belongs to family Dioscoreaceae and is very popular food supplement among the tribal and rural communities of the state of Odisha. The tuber juice is used as cooling agents during summer in southern part of Odisha. Its parts are used as food and medicine among rural and tribal communities of the state. Keeping this in view, an attempt has been made to evaluate the antibacterial activity of Dioscorea alata L. Tuber extracts. Phytochemical evaluation was carried out. Phytochemical screening showed wide pharmacological values of this plant. Presence of tannin, flavonoids and phenolic compounds in all tuber extracts may be responsible for antibacterial and other bioactivities. Antimicrobial activity and MIC activity using Disc Diffusion assay of methanol and acetone extracts was carried out. Both extracts showed prominent activity against Vibrio cholera, Shigella flexnerii, Salomnella typhi, Streptococcus pyogenes and Streptococcus mutans. Results validate Dioscorea alata L. is not only a food plant, but also a good source for formulation of new antimicrobial agents. Further works need to be carried out for pharmacological evaluation of Dioscorea alata L. plant parts.