Dioscorea species: source of saponin derived anti-inflammatory drugs to fight against complex regional pain syndrome

Abstract published

 

International Conference on Neurosciences, Theme: “Brain Plasticity and Neurological disorders”. 9^th to 11^th November 2013, Department of Zoology, School of Life Sciences, Ravenshaw University, Cuttack, India, pp-36-37.

Dioscorea species: source of saponin derived anti-inflammatory drugs to fight against complex regional pain syndrome

Sanjeet Kumar, Nihar Ranjan Singh, Shanti Prava Behera, Shakti Kanth Rath and Padan Kumar Jena

Email-Id: sanjeet.biotech@gmail.com

Abstract

Complex regional pain syndrome (CRPS) or causalgia is a chronic systematic diseases characterized by severe pain and swelling. It initially affects an arm or a leg and often spreads throughout the body. It is a multifactorial disorder with inflammation, sensitization and maladaptive neuroplasticity. The major treatments are scrambler therapy, contrast bath therapy, mirror box therapy, symapthectomy, use of ketamine and anti-inflammation drugs.anti-inflammation drugs are very important to treat this syndrome. There are list of anti-inflammation synthetic drugs such as aspirin, ibuprofen, diclofence etc. Those are used all over the world. One isolated saponin derived compound, diosgenin from Dioscorea species is very common, which acts as aspirin and possess acute anti-inflammatory and analgesic effects. The isolated saponin (3-beta-2-acetoxy-benzoyl-diosgenin) from Dioscorea zingibenensis showed 7.92 % and 14.51 % anti-inflammatory activities at the dose of 126 mg/kg and 252 mg/kg body weight in mice (Mh et al., 2011). Keeping this in view an investigation was made to screen the saponin in three solvents n-hexane, methanol and water with polarity 0.1, 5.1 and 10.0 respectively in tuber of four Dioscorea species i.e. Dioscorea puber, Dioscorea pentaphylla, Dioscorea bulbifera and Dioscorea alata. The species are prevalent in Odisha. Results showed presence of 99.0 % of saponin in water, 33.3 % in methanol and no indication of saponin in n-hexane extract. Further studies are being carried out to validate the anti-inflammatory activity of the isolated saponin of above Dioscorea species. Such investigation will be helpful and will provide base to formulate synthetic drug to fight against CRPS.